Skip to Accessibility Tools Skip to Content Skip to Footer

Medical Marijuana – A Viable Option for the Treatment of RA?

For thousands of years and across many cultures, marijuana, or cannabis, was touted as possessing medicinal properties.1 And its use for both medicinal and recreational purposes is gaining in popularity in recent times. Some activists are advocating its use for rheumatoid arthritis.2 My desire is that RA patients will carefully consider all treatments for their disease. The topic must be raised in public forums and from scientific perspectives. I realize that this article will likely bring about a slate of responses, both for and against. Such is a nature of controversial topics and I hope for a reasoned conversation on this site’s discussion forums.

There are currently 20 states in which medical marijuana is legal. Another 13 states have pending legislation. Some of the laws were approved legislatively and others were voter-approved initiatives.3 Washington and Colorado voters also recently approved recreational uses of marijuana. Some states restrict the use of medical marijuana to a predetermined list of conditions. For example, Washington State approved marijuana for “terminal or debilitating medical conditions” including but not limited to “nausea, vomiting, cachexia associated with cancer, HIV-positive status, AIDS, hepatitis C, anorexia, and their treatments, severe muscle spasms associated with multiple sclerosis, epilepsy, and other seizure and spasticity disorders, acute or chronic glaucoma, Crohn’s disease; and some forms of intractable pain.”4 Rheumatoid arthritis or other forms of arthritis are not directly included in this language or in most state laws except in California. However, most state laws include vague language that could include almost any chronic disease. For example, the Washington State law adds, “Any other medical condition duly approved by the Washington state medical quality assurance commission in consultation with the board of osteopathic medicine and surgery as directed in this chapter.5 Most state laws require that the use of medical marijuana be under the direct supervision of a licensed physician.

In spite of state laws on medical and recreational use of cannabis, the United States federal government continues to maintain that it is illegal to possess, use, and sell marijuana and it is defined as a schedule I substance under the Controlled Substance Act.6 The Food and Drug Agency (FDA) of the United States has not approved it for medical use although they state that it could be approved should research support it.7

There are many chemicals found in the cannabis plant. The chemicals commonly attributed to the medical and psychoactive properties are called cannabinoids with the most common called tetrahydrocannabinol or THC. When ingested, these chemicals attach to receptors in the brain that are involved with “pleasure, memory, thinking, concentration, movement, coordination, and sensory and time perception.” (National Institute on Drug Abuse8)

There are multiple ways to ingest marijuana including smoking, vaporizers, eating, and topical lotions.9 In addition to these methods of delivery, there are also pharmaceuticals pills or sprays that include the active ingredients of cannabis. These include Sativex, Marinol (dronabinol) and Cesamet (nabilone) along with several others.10 Smoking has long been associated with RA risk and severity.11 Like with tobacco, smoking marijuana also produces cancer-causing chemicals.12 If cannabis is to be used, ingesting it in ways other than by smoking would be wise.

The bulk of research studies on the overall use of medicinal marijuana for a variety of ailments produced mixed results.13 There have been few double blind studies, the gold standard for experiments and government approval for drugs, published in peer-reviewed journals. One consistent finding in these studies is that the use of cannabis may help relieve pain. There have been few research studies on the use of marijuana for the treatment of rheumatoid arthritis. In one small study published in 2006, the researchers used a cannabis-based medicine called Sativex. The researchers found that the RA patients who received the drug displayed less pain and higher quality of sleep. But there was no impact on morning stiffness.14 An argument for the use of cannabis to treat nausea that originates from other RA treatments like methotrexate could be made. Nausea is a classic and problematic side effect of methotrexate that causes many patients to stop taking this disease modifier (DMARD).15 There are not, however, any controlled studies on this specific use of marijuana.

In spite of the scarcity of solid scientific evidence supporting marijuana or cannabis-based medicines for arthritis, some groups strongly advocate its use. For example, the group Americans for Safe Access published an extensive treatise on the subject.16 The numerous footnotes included in this article did not include citations so the sources supporting their arguments could not be checked. An article by the National Organization for the Reform of Marijuana Laws (NORML) also advocates for the use of cannabis for rheumatoid arthritis.17 But the references provided fail to build a strong case although they did include the 2006 study mentioned above. It could be argued that the push for medical marijuana by advocacy groups is simply a ploy to legitimize recreational use. It is true that teen use of marijuana is significantly higher in states with medical approval than in states without it.18 It is common street knowledge that just about anyone can walk into a medical marijuana store and walk out with a supply.

An article was recently published in the Rheumatology Network, a publication for practicing rheumatologists, regarding the use of medical marijuana for RA. The physician authors articulated eight research-based principles that rheumatologists should recognize about medical marijuana and RA. Patients should also carefully consider these principles. The eight principles are as follows:

  1. There are hundreds of chemicals in marijuana and their full impact is unknown.
  2. Cannabinoid receptors are found throughout the body and involve complex processes.
  3. The immunosuppressive and anti-inflammatory actions of the cannabinoid system are not well understood.
  4. Solid evidence for its use for pain relief is lacking. Not a single published randomized controlled trial has examined the dosing, efficacy, or side effect profile of herbal cannabis in patients with rheumatic diseases.
  5. The groundswell of advocacy driving the use of medicinal herbal cannabis is contrary to medical opinion.
  6. Smoking cannabis cannot be recommended.
  7. Contrary to common belief, herbal cannabis is not an innocuous substance, either for short- or long-term use, and its effects undermine the primary goals for treatment of rheumatic pain, namely reduction of symptoms and maintenance of function.
  8. There are no grounds on which to recommend herbal cannabis use for rheumatic disease and numerous other pain-management options can be explored.19

While there could be some evidence and reasoning for the use of cannabis for treating pain and nausea, there appears to be a lack of research to strongly support its use for treating RA. There certainly is no evidence to support its use to treat autoimmune disease processes and in fact, it may actually interfere with these processes especially if ingested via smoking. Continued research is needed before wholesale support of the medical community is likely. There is increasing approval by states while the federal government continues to resist. Advocacy groups continue to exert much pressure for its approval and use. There are numerous voices on all sides of the issue and RA patients and doctors must make informed decisions. Debates regarding the use of medical marijuana are not likely to fade anytime soon.

This article represents the opinions, thoughts, and experiences of the author; none of this content has been paid for by any advertiser. The team does not recommend or endorse any products or treatments discussed herein. Learn more about how we maintain editorial integrity here.

  15. Alasan MB, van den Bosch OF, Creemers MC, et al., Prevalence of methotrexate intolerance in rheumatoid arthritis and psoriatic arthritis. Arthritis Res Ther. (2013) Dec 18;15(6):R217. [Epub ahead of print]


  • bones2
    1 year ago

    Been using cannabis oil for 2 months.
    It has vastly improved my disease. Helps with sleeping which is something I have always struggled with due to RA.
    In turn I am getting more rest which could be why my symptoms have improved lately.
    I still inject RA drugs weekly but have not had a painkiller for 2 months which again is helping my health.
    I injest the oil by drinking in tea last thing at night. I wouldn’t recommend day time use as it can make you drowsy .

  • Jonathan Hunter
    5 years ago
  • Andrew Lumpe, PhD moderator author
    5 years ago

    Thanks for sharing the link!

  • carol white
    5 years ago

    Great article. I think it’s time everyone looks past the stigma of teens with the munchies, sitting in the basement listening to Floyd, and consider Marijuana as a possible help to people with all types of diseases/health conditions. Many of our pharmaceuticals originally came from plants, so why should m.j. be left out? Dr. Sanjay Gupta (renowned neurosurgeon) has written an extensive piece on his findings and research, as well. I feel positive that there will be more serious discussions and research in the future!

  • Andrew Lumpe, PhD moderator author
    5 years ago

    Glad you liked the article Carol.

  • Karmel
    5 years ago

    My cousin also with Rheumatoid (hereditary in family) is able to buy the Oil from the Indica strain of cannabis plant. She ingests it (not smokes) Marijuana was legal from 1850 to 1941 and used as medicine in ancient China + Egypt.

    Cousin tells me her rheumatoid is in remission while she is on it so you can see why I’d like other opinions. Unfortunately I live in a State that has not yet legalised Medical Marijuana.

    I figured they must have done trials on Charlotte’s Web medical marijuana in Colorado ? It must be off the FDA poisons list, or further down from schedule 1 poison for Sativex/Nabiximols and Charlotte’s Web to be sold?

    Just a thought ….Opium = Endone, Oxycontin, Panadein Forte are made by Drug companies so I wonder why some company is not doing more on Marijuana/Cannabis ? Colorado made $180 Billion USD in taxes in 18 months.

  • jhoff550
    2 years ago

    Curiouse, what exactly is ur cousin taking and did she stop all her other treatments and just do cannabis?

  • Wren moderator
    6 years ago

    Hi, Andrew! Another excellent article. Medical marijuana absolutely need more rigorous study–as you pointed out, there have been very few so far. And that will continue to be a problem until the Federal government goes the way of some of the states and legalizes its use. As things are now, studies can’t be done because of the illegality of the substance under study. Until it can be studied, we just won’t know much about it.

    I’ve used medical marijuana for RA pain relief here in California, getting it after seeing a doctor and showing him medical records proving I have the disease. I would love to say that it worked wonderfully, but for me, there wasn’t much effect. It might have been the particular variety I tried, or maybe I was just not susceptible to the cannabinoids–I’ve always been tough to medicate as I’ve a strong resistance to pain meds. My husband can take an opiate-based pain med and within minutes, he’s out for the count. Me? It’s like I’ve not taken anything–though those meds DO lessen my pain some.

    I’d like to see more conversations about medical marijuana. I’ve read some accounts about people who have really been helped. My feeling, for the present, is that if marijuana eases your pain without causing any obvious problems, then it should be your right to use it (but also, of course, your responsibility should it harm you in some way down the road). I still hold out hope that perhaps some other type will work better for me. I don’t like having to take opiates to relieve my pain.

    Thanks for opening up the conversation.

  • Andrew Lumpe, PhD moderator author
    6 years ago

    Thanks for the compliment Wren! There aren’t many good choices for pain control as they all come with shortcomings or harmful side effects.

  • Poll