Has anyone else had every blood test remain negative?

RA and all blood tests negative

I’ve had RA diagnosis for 8 months.. classic symptoms..still all of lab tests are NEGATIVE. .positive ultrasound of joints and fluid in joints.. symptoms have have gotten so bad I’m considering quitting work which I really can’t afford to do.. started Humira.. only helps for about a week.. anyone else have every blood test remain negative including CRP and Anti-CCP?


Community Answers
  • Monica Y. Sengupta moderator
    3 months ago

    Hey @k4rand! I know we spoke briefly on my article, “RA or not RA?” so you know I also have completely normal blood work.

    I have been diagnosed for eight years and to be honest, the first year or two were the most difficult while my doctor and I trial and errored many medications. I wish there was some magic combination I could give (though, I couldn’t even I had one – as Alee mentioned above) but keep working with your healthcare team and I know you will find something that works. How long have you been on Humira? Can you try a different biologic?

    ~Monica

  • Dlknight4
    3 months ago

    VECTRD is a test that measures the activity level of your RA. Good way to verify if meds are working or needed as well

  • deb856
    3 months ago

    yes that test is how my rheumatologist measures the progression of my disease. When i feel like im having a flare up, i dont always show it so he monitors it by doing the vectra test.

  • tnanderson616
    3 months ago

    Yes I am also seronegative, thankfully my PCP is an excellent doctor and knew what it was right away. It is frustrating because you can’t help but think in the back of your mind that maybe the doctors are wrong, but don’t fall into that trap. Do exactly as they say, you will be better off in the long run. I fell into the denial trap and the disease did more damage than it otherwise probably would have.

  • k4rand author
    3 months ago

    Thank you for responding.. I can’t deny i have RA any longer. The pain and inflammation has gotten so severe I wish it was only temporary.. but know now it’s not curable. I’ve been on humira for 2 1/2 months. It seems to help 7 out of 14 days.. I’m contemplating trying cbd oil. I’ve heard it really helps.. I’m hoping.. hope you’re having a good day today.

  • Dlknight4
    3 months ago

    I am thinking about that as well. Not sure of the laws in my state but going to start doing the research on it.

  • Mary Sophia Hawks moderator
    4 months ago

    Yes, you are not alone. All my tests were negative, but my symptoms showed. Have they done a Vectra DA test on you? That was the only test that showed RA for me. When I had my first knee replacement for osteoarthritis, the surgeon was surprised to find RA damage on the opposite side of the knee from the osteo.
    Hope this helps. Keep in mind that it may take time to find the right medication for your RA.
    MS

  • Richard Faust moderator
    4 months ago

    Hi k4rand. On top of the excellent information from Alesandra, I thought you might find this story of interest. My wife, Kelly Mack (a contributor here), was diagnosed almost 40 years ago at the age of two. She had joint replacements as soon as he was old enough and has used a wheelchair since her late teens. At the time of her diagnosis they didn’t even do the rheumatoid factor test. Last year, when doing other blood work, her doctor did the test just out of curiosity and, lo and behold, she is sero-negative. So, even one of the worst RA cases doctors have seen can test negative. Note: Kelly’s CRP is routinely quite elevated, but normal CRP does not preclude RA. Hope you find some answers soon and please know that this community is here for you. Best, Richard (RheumatoidArthritis.net Team)

  • k4rand author
    4 months ago

    Thank you Richard.. the more I’m learning about Sero-negative RA, the more common I’m finding that you can have negative labs.. just frustrated that they haven’t been able to get symptoms under control yet. Feeling hopeful..thank you again for the info.

  • k4rand author
    4 months ago

    Thank you for the link..:)

  • Alesandra Bevilacqua moderator
    4 months ago

    Hey k4rand! While you wait for community members to chime in, I encourage you to check out this similar Q&A here: https://rheumatoidarthritis.net/q-and-a/normal-blood-tests/ Some of the answers seem to relate to your question! In addition, these articles may provide some insight: https://rheumatoidarthritis.net/living/seronegative-ra-blood-tests-dont-tell-entire-story/ and https://rheumatoidarthritis.net/living/delayed-diagnosis/ I hope this helps! Thanks for being here with us. Warmly, Alesandra (RheumatoidArthritis.net Team)

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