I’m sero-positive diagnosed Jan this year. On 15mg Methotrexate subculture weekly. Worked well until pharmacy filled Rx with drug from different company. Flare in hands and knees, lower back and neck. My PCP believes lower back pain is RA related but none of the Rheumy’s do. Would live to hear from real people in the trenches as it seems like a no brainer that RA would hit all synovium.