Has anyone had any issues taking Methotrexate and Naproxen together?

So today I went to my local CVS to pick up my normal prescriptions. But today when I went in the pharmacist left me a note saying “Do not take Naproxen on the same day as Methotrexate.” I have been taking both of these meds for a few months now and I have never been told not to take them on the same day until today. I was wondering has anyone had any issues or side effects taking these two together? I will be speaking to rheumatologist about it but I wanted to hear opinions from you all. Thanks in advance!


Community Answers
  • Kelly Dabel moderator
    1 year ago

    Hi there, thank you for reaching out! Taking Naproxen or other NSAIDs, while you are taking methotrexate can increase your risk for certain serious side effects. However, because you may be receiving a low dose of methotrexate, your doctor may decide that you can safely continue to take an NSAID treatment while receiving methotrexate. Great thinking to speak with your Rheumatologist right away! Make sure to talk to your doctor about which drugs are safe to take while you are being treated with methotrexate. In addition to speaking with your doctor, this article may be helpful to you: https://rheumatoidarthritis.net/treatment/methotrexate/
    Hope that helps. Thank you for being part of our community! Kelly, Rheumatoidarthritis.net Team Member

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