Hi Nataly, I'm sorry to hear about your son's diagnosis, however, I'm glad to hear he's experiencing some relief since starting this different treatment regimen! That's awesome! Humira can be taken with or without MTX, and the decision on when to combine the medications is made by your son's healthcare provider based on his symptoms, past medical history, and a variety of other factors. It may be a good idea to bring this question to your son's doctor to see why he isn't on MTX with the Humira, and if there would be any benefit to adding the MTX back into his routine. They might have more information one way or another based on your son's specific case. Hopefully, others can chime in on their experience with this issue as well, however, in the meantime, I've found an article on Humira that I'm hoping may be helpful too! https://rheumatoidarthritis.net/treatment/humira-reviews-how-well-it-works/ If you do talk to your son's doctor, let us know what they say! We'll be thinking of you both! -Casey, RheumatoidArthritis.net Team