Hi. I am new to the forum. I have had RA for about 8 years, serum positive, and was (past tense) positive for lupus as well (10 years ago). I have been on Imuran but had to stop due to liver toxicity, cellcept (diffuse pain), prednisone (developed Cushing’s). I then went to 25 mg methotrexate injection. Later Orencia was added, but still wasn’t enough. I then moved to Rituxan. My first dose went ok. My second dose caused me to have trouble breathing in the infusion chair, increased BP, low O2 and spike a fever. The nurses came over, stopped the med, put me on oxygen and I recovered within about 20 minutes. They continued with the IV at a slower pace, but I called my Rheumatologist and opted not to continue with that med. I went back to Orencia. Not too long after that, I switched to Xeljanz and things have been ok for 2 years, BUT NOW….
I just had a PFT and found that my DLCO is 56%. The air I breathe isn’t getting the O2 pulled out of it and transferred to my blood. Is this happening to anyone else? They ruled out COPD. I was reading something about Rituxan causing Pulmonary toxicity in some cases and was curious if anybody had experienced this? The doctor is ‘researching’ some things, but I am short of breath and thought I would do some research of my own while I wait. The obvious thought would be interstitial lung disease.
Has anybody gone through this?