Greetings all! I’m hoping to hear others experiences switching from one TNF-inhibitor to another.
A bit of background: I was diagnosed with RA 2 years ago, Prior to dx, my regular diet was already very close to recommended anti inflammatory diet – I ate healthy, and was physically active (lots of walking, hiking, kayaking). My initial RA flare came on very suddenly and was very severe, and progression seems pretty aggressive. I went the usual route of oral MTX (seemed to help initially then quit working), MTX subQ (seemed to help initially then quit working, plus I couldn’t deal with the debilitating fatigue MTX caused). I next tried leflunomide (seemed to help initially then quit working…..hmmm, seems to be a pattern here!). I finally agreed to try a biologic, and had my first dose of Humira May 28.
Fast forward to today. My body does not like Humira. At all!! After 2 weeks of feeling so awful (my list of side effects reached 10 – I think I’d rather deal with RA pain!), my rheumy is switching me to Enbrel.
Which brings me to my question: both Humira and Enbrel are TNF-inhibitors. Meaning they have the same action in your system. So if you have an extremely bad reaction to one TNF-inhibitor, why wouldn’t you expect to have the same reaction to another? I do have a call in to my rheumy to discuss with him (and it will be a while before pre-approval/prescription fill from specialty pharmacy, etc), but I’m curious about others who’ve had a negative experience with one (not just that it didn’t work, but serious and/or multiple side effects) but not the other.
Sorry for the lengthy post. Helps to ramble in a setting where everyone understands the frustrations. Gawd I hate this disease!!