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Treatment

Xeljanx?

  • By DianaP32

    Is anyone one Xelijanx. and if so how is it working for you? I got it prescribed, but I’m not ready to take it and I’ve been in pain lately.

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  • By ktinflorida

    I’m on it. I have been on it and 25 ml injectable methotrexate for 2 1/2 years. It is the best med combination for me so far. I love that it is just pills and not an injectable or an IV. It makes them very portable. It also treats my RA without dropping my white count too low. So far, other than the retail price, I have nothing bad to say about this med.

    What is your concern with starting this med? Is this your first biologic.? I was in pain and on narcotics before this. It took about 3 months to feel the full effect.

    Let me know if there is anything I can answer for you. Everybody doesn’t have the same experience, so I can’t say you will have the same success, but the best treatment for oain is to control the disease.

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  • By DianaP32

    Hi!,

    That’s good, I was on pill version of methotrexate, but I got really sick from it so I tried other meds. So now, I was put on Xeljianx but I haven’t taken it yet due to not having the TB test done. I am just afraid of the side effects.

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  • By ktinflorida

    Why did they not switch you to the injectable version of MTX? It absorbs better which makes it work better and I don’t get sick on it like I did with the pills. It is odd they gave up on it so soon unless you declined the injectable. I had to go off MTX for a few months and the Xeljanz alone did not work for me.

    What side effects specifically worry you? I don’t remember reading anything very scary, but then after my last biologic, which listed instant brain death as a side effect, I’m fairly unflappable now.

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  • By DianaP32

    They did offer me the injection but I couldn’t keep up with as it was also making me sick and I didn’t have it in me to object myself all the time. I’m afraid of all the side effects it comes with. Like I work on an environment where I’m around people all the time and I don’t like how it will surpress my immune system therefore making more able to get sick. 😣

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  • By ktinflorida

    Yeah, I can’t inject myself either. Glad to know I’m not the only wimp out there. ;>) I have a friend do it. I also take phenergan for nausea on those bad days. They happen less often now. I also use ginger.

    A biologic shouldn’t drop your white count any more than MTX. I assume your doctor is monitoring it. Do you know what it is? On my other meds my white count went down around 2. Now it hovers around 4.4. It isn’t normal, but it is closer to normal than it has been since I got sick. I still get sick, but not as much. Do people at work know you are sick? Would they be respectful and try to stay away from you when you are sick or do you work in a customer service type thing where you have no control over what is in front of you? That is much harder to control.

    All I can tell you is that not taking meds to suppress your immune system will allow the disease to progress which will cause you bigger problems sooner than you think. Unfortunately, there are no easy solutions to RA.

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  • By RondaLopez

    Hi I’m new here but not to RA. I was diagnosed 10 years ago. Went to a new Dr, he put me on Xeljanx and I am really scared to start it. I have been on Enbrel for about a year and a half. No other drugs for RA. I’m doing good so just do not understand the change. My problem is I am so scared of this drug. Can anyone help me out here??

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    • By ktinflorida

      Why are you scared of this drug as opposed to the Enbrel? I’m happy to address your concerns, I just don’t see it much difference. They are both biologics. They can both cause liver damage. They both impact your immune system opening you up to infections and cancers. Is there more to it that you are concerned about? In my opinion there are scarier meds, like Rituxan. That can cause sudden brain death. THAT is scary!

      I’ll do my best to help with your questions. Personally, I like not having an IV or injection. Pills are great!

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  • By bluegrassgran

    Hi I’m new to this site as well been diagnosed 11 years have been on Methotrexate without success then on Humira I got very very sick had to come off that they put me on xeljanz it’s not working well enough so now he wants to prescribe Enbrel has anyone had any success with that? I feel like I’ve been in a decline for the last 2 years more flares more pain is this just because of xeljanz isn’t working or is this part of the process? Thanks for any and all help

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    • By Richard Faust Moderator

      Hi bluegrassgran. The prospect of switching medications is understandably nerve wracking. Every person has the potential to react differently to each treatment. We certainly have members of the community who have had success with Enbrel. This article from our editorial team gives and overview of the drug: https://rheumatoidarthritis.net/treatment/enbrel-reviews-how-does-it-work/. Also, thought you might be interested in this article from one of our contributors about a doctor who would not let him settle for having occasional flares and his RA not being quite under control: https://rheumatoidarthritis.net/living/the-good-doctor/. Wishing you the best. Richard (RheumatoidArthritis.net Team)

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    • By Piano14

      I’ve been on Xeljanz XR for a year and a half now. It’s the first modifier that seems to work for me. The Xeljanz 5 mg didn’t work for me. I just got sinus infections. I was on Enbril for 10 years and hated the ups and downs associated with the shots. I’d only have 1 good day out of the whole week. Same with Humara which I was on for 5 years. I was always afraid to change. But for me, I’m glad I did. Xeljanz XR is consistent so I have a controlled level of swelling/pain that is easier to manage on a day to day basis. I have less side effects than the other mentioned drugs. When I feel a sinus infection coming on, I cut back my dosage for a day. I hope you find what works for you. I don’t think you need to be afraid to try Xeljanz if the others aren’t working.

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  • By RondaLopez

    Hi I have been on Enbrel for about 4 years now. It is working well for me. I have been through about all the drugs for this with no success until the Enbrel. They wanted to change me to the Xeljanx but no way after researching it. So I finally talked my new Rhumatoligist into keeping me on the Enbrel. It has been around quite awhile, I personally trust it, my numbers went from a very high 78!!! To now it is at 21 . I’m not taking anything else with it. Good luck, I too have been through the terrible flares and had to take predizone for that. It helped but I also gained about 60 lbs. So now I’m back to a size 8 which helps. I haven’t had a flare in years. So I would try it if I were you, we are all different but hopefully it works for you. This diease is terrible as we all know. I so wish they would concentrate on a cure.

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  • By Kimberly

    Hi Diana,
    We’re in the same boat! I start Xeljanz XR today after waiting a month since last infusion of Orencia (horrid side effects) Before that I did a year of Simponi. I’m both scared and optimistic. Let’s keep in touch and compare our luck!

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    • By spanky

      My doctor is supplementing my MXT pills next month with SImponi infusions. Did it work the year you used it and why did you stop?

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  • By jsmartin81

    Hello! I have tried, and failed, Mtx, Humira and Stellara. I had an allergic reaction of hives and swelling to the last. Since February I have been on continual rounds of Prednisone, still with incomplete pain relief. I started Xeljanz 7 days ago and I am experiencing quick relief! My right knee, which has hurt for months, no longer hurts. Also the joint in my pointer finger on my left hand has been swollen and painful and that is also better by the day. Almost gone. It no longer takes me three hours to shake off the pain I wake up with everyday. I’m only 36, I refuse to live in pain. And I am kind of thinking this could be the one that puts me in remission of flares. It has not addressed my psoriasis yet, but without pain I’m not sure I even care about that. I had almost forgotten what it was like to feel good. Plus, I so far have not had any side effects such as upset stomach etc. I would definitely recommend this drug for the ease of use and for those who have failed on injectables as I have. Best of luck to you.

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