Hi pansypotter. Always a great idea to check for contraindications when adding medications. I did find that methotrexate and alendronic acid can increase the potential for liver or kidney function issues. I did not see anything concerning the timing of the dosages. Are you already having regular blood work to monitor for this? I ask because these blood tests are often done for those on methotrexate. My wife, Kelly Mack (a contributor here), was on methotrexate for years and regular had these tests. As Alesandra mentioned, your doctor should be able to provide additional guidance. Best, Richard (RheumatoidArthritis.net Team)