I am now on my 3rd injectable biologic treatment. I've tried Enbril, Humira and now Simponi. I'm at a crossroads here. Each of these drugs ended up giving me some serious upper respiratory infections, to the point where I had to take off work. The infections are understandable. After all we're talking very strong immunosuppressants here. It's to the point now where I have to decide, stay on a moderate dose of prednisone ( the only thing that seems to work to control my stiff joints) and "enjoy" it's long term side effects or continue with coughing, wheezing and losing time and money from sick days.. I've been taking prednisone ( between 4 - 20 MG daily) for at least 10 years now. I dream of someday getting off prednisone but that just does not seem likely. I don't know if I'm looking for answers, advice or just an ear.