Hi . As the excellent information from notes, up to a third of cases are seronegative. My wife, Kelly Mack (a contributor here), was diagnosed at age two, almost 45 years ago and also happens to be seronegative. Your frustration is certainly understandable. Are you on a treatment that helps at all with your symptoms? Please know that people her understand and feel free, if you like, to keep us posted on how you are doing. Best, Richard (RheumatoidArthritis.net Team)