I have CVID that caused the autoimmune RA. I have been on Methotrexate for 16 months and my RA has not improved. The Methx made me feel awful the whole time and my RA severity has slightly increased. I am unable to try Biologics because of me Immune issues. I started 10 days ago on Plaquenil which caused an allergic reaction...so now I 'm off that and will try Xeljanz. Praying this works for me. In my mind I'm thinking my with my CVID (which I do IGG infusions weekly) to build up my immune system and the DMARDS and other RA meds suppress your immune system the two are at war with each other.....but I'm truly praying I can find a medicine that works for me!