I’m wondering if a significant flare while on Remicade typically means it’s time to change again, or if it’s possible that it may start working again? I have been on both Humira and Enbrel in the past. They both helped briefly, but by about 6 months my symptoms returned. I started Remicade almost 5 months ago and had great results. THEN, I caught the flu, which postponed my dose 2 weeks. Right after my last infusion, I went through multiple major life stressors: sleeping in a chair in my mother-in-laws hospice room, followed by her death and hosting many family members for her funeral. Less than a week later I started a 3 week trip babysitting grandkids in Seattle then LA, while their parents travel. I get home a few days before my next infusion. Is it possible with a decrease in stressors and activity may allow the Remicade to work again? If not, I’m sure we will be going to a non-TNF choice next.