Back to all discussions

Low-Dose Naltrexone

Has anyone tried Low-Dose Naltrexone? I found several websites written by doctors who have found it useful with their RA patients. Would like any feedback from anybody who has tried this. Thanks.

  1. Hi Introvert. I did some research and suspect I found much the same information that you did. This article from the National Library of Medicine outlines research into the use of Naltrexone for known inflammatory conditions and finds some efficacy: This study and others note that the literature on the subject is quite small and larger studies are needed. I can't offer any personal experience on the subject, but perhaps some others have information to share. Best, Richard ( Team)

    1. Hello! My rheumatologist recommended low dose naltrexone and I did just start the medication one week ago. It’s only been a week but I feel good so far. The side effects are minimal if any at all.

      1. Cindy67,
        There are several websites with the latest results about LDN and I believe they have a list of doctors who will prescribe it. The main one is LDN spelled out I've been on it now for about 8 months and while it hasn't reversed the symptoms, it has helped with the pain. I also have more energy and no brain fog now. Still no side affects at all. Hope this helps.

      2. Hi,

        Thanks for your reply.

        I already have a prescription for LDN but not from my own doctor or rheumatologist which is why I want to come in contact with rheumatologists who actually prescribe it like your own doctor. I will try and look them up and contact them.

    2. Just make sure you have clear identification that you are taking Naltrexone in case you get into an accident, need pain relief, etc. Naltrexone will compete for opioid receptors, and it can take very high doses of pain medication to get past that. And it can take several days to weeks to have the effects wear off. Something to consider if you are going to have surgery, a root canal, etc.

      1. Frazzled,

        I'm not sure where you are getting your information.

        Actually, LDN only temporarily blocks the endorphin receptors. The peak blockage lasts only a couple hours; the reactive increased endogenous endorphins last maybe 16-18 hours (may be individual), although I suspect that after a year or two on LDN, the body gets "trained" enough that if you miss a dose, the endorphins may continue to reset each night for a few nights without even being blocked by the LDN--that seems to be true with me.

        If you are taking naltrexone or naloxone at the higher doses (e.g. 50 mg), say for opiate withdrawal, then yes, there would be an issue. But LDN for autoimmune is usually in the 0.5 to 5.0 mg range. I'm on 2.5 mg, enough to 95% reverse (manage) my RD.

        Actually, I've found that 3 years on LDN has raised my pain threshold, as well as my mood and energy, due to the increased endogenous endorphins (and much less inflammation.)

        LDN is actually being used in combination with an opiate for opiate addiction tx. (Suboxone)

        And there are other non-opiate pain tx that aren't blocked by LDN.

        So the situation is a bit more nuanced than you are portraying.

        For more info on my LDN tx, see my posts in Alternative Tx. For more info in general on LDN, check LDN Research Trust in the U.K.


    3. Thanks for the feedback everyone. I've been on it for a while now,and it is helping some. No side effects at all, which is great.

      or create an account to reply.