Hi Franklin. The technical name for the drug you are referring to is leflunomide. It was originally marketed under the name Arava. Pregnancy can be an issue with this drug and one of the warnings is that women who are pregnant or planning to become pregnant should not take it. This article from our editorial team takes a closer look at leflunomide, including warnings and side effects:
https://rheumatoidarthritis.net/treatment/arava/.
I am not sure what the "opposite" tablet the doctor advised might be and the doctor should clarify this for you. One medication that could be prescribed, if it was not already, would be folic acid. Leflunomide can affect the liver and folic acid is often prescribed for use in conjunction with medications that do this to help clear the liver.
Has the rheumatolgist suggested a new treatment regimen? This article from our editorial team looks at various treatment possibilities, with links to more specifics: https://rheumatoidarthritis.net/treatment/.
I hope this information proves useful. Please know that you and your wife can always come here for information and support. Keep us posted on how things progress. Best, Richard (RheumatoidArthritis.net Team)