Hi Marcia ~
"general ill feeling, fever, chills, cough, body aches, flu symptoms" are all listed as side effects of Rituxan - so I am sure you are not the only person who has experienced this feeling! But whether this was your first Rituxan infusion or your 50th, it is always important to let your doctors know if you have any weird side effects afterward that you think might be related. Your doctor is the very best person to evaluate the severity of these symptoms and help you decide what to do. And even if your doctor suggests increasing your dose of prednisone (which it doesn't sound like you are interested in doing) that doesn't mean you have to do it. If you don't like a suggestion your doctor makes regarding your treatment remember you can always ask what other options you have!
Best of luck and I hope you get to feeling better soon!
~Mariah~