, first off, I am sorry you and your husband are dealing with this. Watching a partner suffer is incredibly gut wrenching, I know.
I wish I had some magic answer for you, but, unfortunately, it can take a fair amount of time and a lot of trial and error to find the treatment that works best for each individual. I know. That's a pretty disheartening answer, especially when you're already feeling pretty exasperated by the treatment process.
Have any of those treatments brought your husband any measure of relief? I only ask because many individuals do experience (temporary) relief with treatments like prednisolone, but they sometimes have to stop the medication due to side effects or concerns over long term side effects from steroid usage.
Has your husband's rheumatologist been communicating well with you and your husband?
While OA does add some complexity to your husband's situation, it shouldn't cause that much of an issue in finding effective treatments.
It really probably boils down to what I wrote above -- it sometimes take time and trial and error. That said, having the patience and strength to endure that when you are hurting and in pain is easier said than done.
Please know you and your husband are not alone here! I know it can feel like no one understands what you are going through as a couple, but we have a large, diverse community that knows what it's like to be in your position.
Please don't hesitate to reach out if you have more questions or even if you just need a safe place to vent.
I hope the next treatment your husband tries does the trick and he starts feeling better asap.
Gentle Hugs, Erin, RheumatoidArthritis.net Team Member.