I have been on mtx before and while I didn't experience those symptoms I can say that over my 30-year RA career, I have had side effects that I couldn't believe were linked to my illness, but ended up being linked. It's best to check with your rheumatologist to see what they think, and in the meantime, track everything you eat and do for a while and see if there's a correlation between that and the symptoms you are having. I have done that before and found links sometimes in things that I'm sensitive to, like for me sugar is an RA symptom trigger. Let us know if there's anything we can do to help! Keep on keepin' on, DPM