Hi . Sorry you had this allergic reaction issue. The trial and error nature of finding an RA treatment is one of the more frustrating aspects of the disease for many in the community. I can't personally speak to Cimzia, but I did note that the different studies seem to cite the 24 weeks as the point that more than 50% reported improvement. This includes those for who the medication does not work, which will pull the time frame further out. Some do report noticing an effect in as little as a couple of weeks. I noticed that the Humira site also states that results could take 24 weeks or longer (this statement actually seems fairly standard). Hoping you will see results fairly quickly. Best, Richard (RheumatoidArthritis.net Team)