Hi Laurie, Sorry you haven't had much pain relief. It's a good thing that your doctor is wanting to change your treatment combination. If the disease-modifying drugs (DMARDs) like Arava and Methotrexate aren't enough to keep your RA in check, then the treatment protocol calls for adding a biological like Humira. Research shows, and many patients find, that a combination of a DMARD and a biological works well. And it's not uncommon for patients to need to try multiple combinations to find the one that works best for them. We're all different and respond differently to medications. I'm currently on methotrexate and a biological and it's working for me. But that is after trying many combinations. I hope it works for you! Andrew