I have had RA for about eight years. I have tried Sulfasalaizine (did not help), Methotrexate (helped but caused pneumonitis so I had to discontinue) and am now on Humira. Humira with Citrate has caused me to have local reactions that kept getting worse with every shot. The last injection caused me to have a raised, warm, red rash with blisters at the injection site. My doctor is now going to try plain Humira. The Humira does take the edge off of my symptoms. I am wondering if anyone else has had this type of reaction to Humira and if so, what was the next medication you tried. Thank you.