No serious side effects here, but there was the tedium of going through eye tests every six months or so. You have to put your head in a big cardboard box and press the button when there is a dot appearing on the screen. It is the height of tedium, yes, but so is everything else with rheumatoid arthritis. Plus, it’s worth it to make sure that your eyesight isn’t fraying around the edges. In the end, though, the med didn’t really work for me so I ditched it and moved on, but it was worth a try and it was a step that got me to the meds that did work! Keep on keepin’ on, DPM