Was diagnosed last Jan and started MTX (injection) folic acid and prednisone. Started Plaqunil in June and able to get off prednisone in October. I have been able to tolerate all meds very well, no hairloss, not feeling overly sick. Thought I was managing quite well. Now the big bummer..had a suspicious mole checked, diagnosed with Stage 2 melanoma. Between the excision of the site and new surgery coming next week for a sentinel lymph node biopsy, been off and on the MTX for several weeks. Already feeling the pain and stiffness returning. I am so fearful of infection after the upcoming surgery but I have to have this done. I really don’t know where this came from. The MTX, the RA? There is not much family history of melanoma. What in the world have I gotten myself into here??