I've tried Prednisone, methotrexate/folic acid/sulfasalazine, Actemra, humira, naproxen, Meloxicam, ibuprofen, aspircream, and now my latest medication routine is Arava 20mg every other day plus sulfasalazine 500mg 2x a day. It's been 2 months since I've started this combination of drugs. I'm having a minimum of 3 flare-ups a week. So frustrating and depression. While in a flare up I'm nearly completely immobilized. Heeelllppp!!