I've been going to a pain management clinic for several months and I'm really frustrated. Because my pain is constant, significant, generalized, caused by RA/RD, Fibro, Pseudo-gout and degenerated disks/vertebrae and hasn't responded to 28 of the moderate to strong analgesics currently available, the Dr. directly prescribed opioids. After taking pills for one month without relief, I was prescribed Buprenorphine patches. Two months on the lowest dose (5 mcg/hour) didn't produce any effects, so the dose was upped to 7.5 mcg/hour. I'm on the third weekly patch and I haven't noticed any reduction in pain level, so I fear that the dose will be increased again, with the added risks. I haven't had any negative effects either, not even the common bowel problems.
I've reseached numerous academic papers and found out that a very small percentage of the population is opioid resistant. This resistance can be due to two facts: a mutation of a certain liver enzime or lacking enough mu opioid receptors in the brain. I believe there is a test to determine the enzime mutation.
Is anyone here opioid resistant? I'll be talking to my Dr. about this possibility at the next appointment, but wonder if anyone has experienced this situation and what may be next.