Three and a half years ago after feeling so very tired and achy for months and months I woke up at 4:30 a.m. in such agony that I woke my husband saying, "Please help me." I couldn't move without screaming. He put me in a hot bath and I began to feel that I could move a little. Soon I was diagnosed with Polymyalgia Rheumatica even though I had a normal sed rate. I did show an elevated C reactive factor and after a day or so of 15 mgs. of predisone, I began to feel better though still in pain. A few months later my fingers and knuckles swelled and I was checked for RA, but all my blood work was normal. I took prednisone for three years reducing my dosage as much as possible and finally stopped seven months ago; I hated it so much. Since then my blood tests have all been normal even though my symptoms have worsened so that I now hurt in every joint in my body especially my wrists, fingers, knees and neck. My voice is continually hoarse and my throat is sore. I recently went to a neurologist for a nerve conduction study and EMG and was negative for carpal tunnel. I feel as though I am coming down with a virus and if I didn't have pain medication I think I would be suicidal. A blood test last week again was negative for everything except elevated liver enzymes (AST 60, ALT 69). What could that mean, I wonder? I think I have seronegative RA, but my doctor says no. He wants to see a positive rheumatoid factor. I tell myself to be patient that whatever is wrong with me will become manifest in time. And no one can tell me that I am not sick.