I have diabetes & RA. I take plaquenil. So far, it seems to help with the inflammation but the side effects concern me. I have to get my eyes checked every year and have blood tests done periodically for both diseases. I do notice that glucose readings do seem to increase when there is more pain. I get leg cramps, nerve pain and am always fatigued. It seems like I can’t even walk normally and lose my balance. The combination of the two diseases is pretty depressing at times. I mainly take Alene and use heat & massage to ease the pain. The pain is mostly in my fingers, toes, ankles, hips & back. I see a Rheumatologist as well as a Pain Management Center. Shots make my glucose numbers rise and help a little bit but it doesn’t last that long. Everyday is a challenge so I can understand the concern.