caret icon Back to all discussions

What is the best way to take Methotrexate?

What is the best way to take methotrexate?

  1. Hi Mffriend. Methotrexate is one of the most prevalently used medications for RA and many are successful with both the oral and the injectable form. For your protection, we cannot give medical advice over the internet. I can share with you this article from our contributor Monica on her experience with methotrexate: https://rheumatoidarthritis.net/living/methotrexate-negative-side-effects/. She did better with the injection. Others do fine with the oral form and prefer the ease of use. Your doctor should be able to provide further information on the pros and cons of each. Best, Richard (RheumatoidArthritis.net Team)

    1. I did better with the injectable form of MTX when I was taking higher [20mg] doses. But when I went on Humira and my MTX was cut to 7.5 mg a week, I went back to the pills.

      1. I learned that discussing Folic Acid supplements with your doctor is very important when on MTX for control of side effects. And that there is a wide range of dosages for both MTX and Folic Acid. I am glad to hear from others that they tolerated injectable after not tolerating oral very well. I didn't tolerate oral methotrexate as the dose went up. It has been suggested that I may try it again with my newest biologic at a lower injected dose. And that we be more aggressive with the Folic Acid dosing. With hope and best wishes, Jo (moderator)

        1. Not at all. it gives me pneumonia! twice in a row, dr said he could give me a shot so i wouldn't get it again, but thats 1 in 1million. i got it again. RA figured it was the MTX. now nurses, say why are you allergic to MTX, as if it gives me gas, "NO IT GIVES ME PNEUMONIA! Spell that twice! Good luck with that drug. yeah maybe i'm screwed without it, but am i worse off with it? should i take the vaccine? with RA im suspect for Stroke and heart attack, if i take vaccine, i get blood clot. Nah,,, i'll let nature take it course, maybe RA is saving me from the Bio Weapon Bat Virus unleashed upon US, by our own government, if china really did it, we would be at war, but the US paid for the research and gain knowledge of the bat virus, china just couldn't contain it.
          we are killing ourselves, and the enemy is US, the govt wants you to take the vaccine, every time they came up with an idea, they were wrong! i think you should think twice, we already have the best T-cells known to man and bat.
          enjoy. have a great day!FriendOrFoe




          1. yes, i did get PNEUMONIA twice, why would i make that up.
            what was amazing to me, was the fam dr, said i could give you a booster/vaccine, but chances are one in Million you get it again. I didn't take shot. I did get PNEUMONIA again, i should have bought lottery tickets, but one bet better, I did LIVE!!! .


            i take actemra every week, a weekly biologic, i guess it works, i just don't know,
            i have RA, diabetes and asthma - i don't think the actemra works, as i am always, flarring!


            My RA, DR. says with my diabetes out of control, my RA is out of control. so i did get out of control, but i'm ignoring the ignorance of the above logic.
            my body is out of order, i am italian and somewhat heavy, my digestive system is out of order, i always have indigestion and digestion issues:


            so i think there is more to this issue than is showing its face. As Al Pacino said - YOU ARE "ALL OUT OF ORDER" and

          2. we say it often but it's true, RA impacts everyone a little differently. It sounds like you had an unusual experience. Our editorial team has an article about Methotrexate and its symptoms that might be interesting read for you or anyone else who wants to learn more (https://rheumatoidarthritis.net/treatment/methotrexate). It can be tough with RA to know how certain medication will respond to our body - and unfortunately sometimes that looks like trial and error. - Reggie (RheumatoidArthritis.net Team Member)

        Please read our rules before posting.