Hi 1ReeRee. Thanks for the question. Everyone patient's reaction to a medication like Humira may be different. That said, weight gain is a potential side-effect. There are numerous potential reasons for the weight gain, such as the medication actually impacting the immune system, a change in metabolic rate, fatigue, and others. This article goes into great detail on the potential causes of weight gain from Humira: https://mentalhealthdaily.com/2018/02/02/humira-adalimumab-weight-gain/. Your doctor should be able to help you identify what may be impacting your particular case. Best, Richard (RheumatoidArthritis.net Team)