Yes; I have given up wheat entirely & last time was almost full year. I did not notice any difference but: we are all different & worth a strong try.
I am strict Vegetarian almost a full year & do not miss animal protein at all (as child I disliked all animal products; chicken pork beef. I am thinner; dropped 40 lbs but that maybe steroids. I was Vegan & my protein low- having Total Shoulder Reversal Replacement Surg 10 was ago: added dairy.