Hi . I can't personally speak to this, but I am familiar with some patients who experience fatigue following the shot and know that some medical sites report it. For example this site notes that "Fatigue is a common symptom in patients with inflammatory immune diseases. Patients may also experience fatigue as an adverse drug reaction of biologics used for an immune-mediated inflammatory disease. This was reported by participants in the Dutch Biologic Monitor, a longitudinal observational cohort study using the Lareb Intensive Monitoring (LIM) system:" https://www.lareb.nl/en/news/fatigue-associated-with-biologics. It is important to bring any potential side effect to the attention of your doctor. Hopefully others will chime in with their experiences. Best, Richard (Team Member)