Hi . On top of the excellent information from Latoya, I want to share that my wife, Kelly Mack (a contributor here), was, like you, on methotrexate for many years. She was diagnosed with a severe case at age two, 47 years. Her rheumatologist eventually switched her to a biologic. In her case, he started her on a biologic alone, with the option to add back methotrexate depending on the response. He did this to try to limit the impact on her immune system due to a lifetime of RA and treatment. That said, there are plenty of people who successfully use both. I also want to share with you this article from Kelly on questions for the doctor: https://rheumatoidarthritis.net/living/questions-for-the-doctor. It could be helpful in charting a path forward with your doctor. Please feel free to keep us posted and to ask additional questions. Best, Richard (Team Member)