Hi . I know that gaps in medication/treatment can result in the return of symptoms. My wife, Kelly Mack (a contributor here), has certainly experienced this when stopping for medical procedures, as have others in the community. Our contributor David wrote about issues related to going off Humira: https://rheumatoidarthritis.net/living/stopping-starting-humira. That said, I need to note that we are not medical professionals and I don't know at what level three days off of hydroxychloroquine can impact symptoms. Of course, the stress of dealing with a sudden medication issue and getting that straightened out can certainly be a risk for increased symptoms as well. Your doctor should be able to give you further information and check for other possible causes. Best, Richard (Team Member)