Hi, I just wanted to ask if anyone has experience of information related to rapid onset of new symptoms. I have been taking methotrexate for nine weeks, I have not had any improvement in symptoms and in fact seem to be getting worse. I was unable to take prednisone due to severe swelling in my feet after four days, so I have been taking celebrex 400mg per day which has achieved a reasonable reduction in pain. I recently reduced this to 200mg per day only to be hit by a terrible flare. So I think I will be returning to 400mg per day for now..
Anyway, for the last few weeks, I have noticed very obvious new symptoms going on. I am going to have to use some childish terminology to explain as I can't find any other words that describe it. My wrists and ankles have started to "crack" and are very sore and "itchy" inside. My hips and knees have started to "pop" and my shoulders are clunking alot on movement. My neck has become "sticky" and when I turn and move my head it feels sort of stuck and makes creaking sounds. Today the pain in my neck has led to a migraine which has flattened me.
I wonder if these sudden worsening of symptoms are related to methotrexate treatment, and will ease off? Or can symptoms suddenly worsen in this way? I have a rheumatologist review in three weeks, but feel as if I'm losing my way a bit at the moment.
Any advice would be greatly appreciated.