Hi . I can't personally speak from experience with Simponi Aria, but I did a little research and did not find sadness or depression cited as a side effect. That of course does not mean your experience is not related to the medication. If you haven't already, you should bring this issue to your doctor. In fact, after trials, a primary way that side effects are reported is by doctors and patients inputting them into the FDA reporting system. Hopefully others will chime in with their experiences. Hoping you get some answers and feel better soon. Best, Richard (RheumatoidArthritis.net Team)