I am feeling pretty low today. I have been on three different medications for RA since June of this year. I have experienced either debilitating side effects (MTX) or a reaction that makes it so I can't take the medications any more. Cimzia caused a ramp up of nerve issues, Hydroxychloraquine cause erratic heart beats and chest tightness and crazy orthostatic hypo tension. I have a prescription for Orencia waiting for me but I am flat out exhausted and feel too anxious to try another one of these meds. I am not sure where to go from here. I'd like to get the set point device, possibly but it is not available in Utah, where I live, yet. I have often had negative reactions to medications. I tell all my doctors this, but feel like they don't believe me until they see for themselves and even then, I sometimes still get the side eye. As if I am trying to have negative side effects or reactions. I didn't even look at the side effects too much for the last two meds as I wanted to have a positive experience so badly. I am almost considering doing nothing for meds and trying to find alternative treatments. Though I know there aren't many if any, that have large studies to prove they are worth it. But I feel like my body can't take any more of what feels like poison to me. Very discouraged today. I'd love some advice or thoughts. I have been diagnosed with RA and mixed connective tissue disease. I have an underlying issue with neuropathy that might be RA related. I have some mild joint pain in my hands, sometimes feet, hips, knee and elbow. But joint pain has not been my biggest issue. That would be extreme fatigue and headaches and some pleurisy. I have PVC and one other arrhythmia heart issue that is caused by a congenital issue. I think it is hard because most people experience so much joint pain and maybe these meds feel like a relief. But this is not my experience and I wish there was something that would work to help my symptoms without making me feel so much worse. I need to function first and foremost. Thanks much.