I am a wildlife professional seeking information on the rabies vaccine series/booster and the interaction with DMARDs. Rabies vaccine is killed, so it is safe to have the injection, but my understanding is DMARDs can interfere with the immune response and the ability to produce antibodies. I take 12.5mg Methotrexate orally per week. I needed a rabies booster series for work due to a possible exposure, so I am stopping Methotrexate for two weeks. I could find very little guidance on this, or if it was even necessary. My doctor was not really able to help. There is a study on Flu vaccine that showed a two week break from DMARDs resulted in greater immunity. Thanks for your help.