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What next ?

So I've now tried embrel,humara,orencia,and rinvoq.
Of all 4 rinvoq has had the least effect on my RA, if anything it's gotten worse.
I go back to my rumitoigest next week and im just wondering what might be my next option. I'm so tired of all these meds not working . the cost of them are crazy and there's no way I can afford them without the copay programs . but enrolling is a nitemare in itself each time .... But I'm ready to try anything at this point . I really hate going to bed now because every nite I wake up in so much pain in my hands that its almost unbearable. It's now been 3 yrs since I was diagnosed : (

  1. It does often take sometime to find the correct medication and the right doe. I do hope you are giving them time to work and that you are using them in conjunction with any medications (usually DMARDS, and NSAIDs) that have been prescribed.

    I have used five biologic medications over the last 20 years. Non less than one year and two for a total of o15 years. My doctor has a general rule that if I change I have to stay with a medication for about 1 year t least. One i changed after seven months but otherwise I have stayed with it for about one year.

    I know different rheumatologists have different standards for treatment so it is not uncommon to find different starts (there is no exact right way to do this). I wonder if you might ask your doctor for a VECTRA test, to get a baseline of inflammation so it will be possible over time to see how tings are progressing with your biologic.

    I wish you the very best on your journey. If you get the chance let me know how things are going? I am interested in your journey.

    rick - moderator

    1. I am so sorry you're going through this. I want to say that you're doing everything right. You're trying different meds to see what works for you. This is unfortunately a common scenario where it's a trial and error process. I know that doesn't change your situation, but know that it is not just you. I am sharing a list of other prescription meds for RA - some you've tried already and some you haven't. But it might offer some perspective in terms of just knowing what's out there. Please let us know what your rheumatologist suggests after your visit next week! - Reggie ( Team)

      1. I have had Prednisone, Methotrexate, Embrel, Orencia, and now I am on Xeljanz which has made a huge difference in my life. The others helped but I was still in pain, and very bad fatigue. Now I can get back to my life and do most things I used to.

        1. It is so tough trying "wonder drugs" without success! I know of nothing else that costs that much without any guarantee. In May I will trial my 6th biologic. I get discouraged, too. But my goal is to not let this feeling last too long. I try to enter each new drug regimen with hope. If I'm not hopeful, I'm afraid my brain will counteract the new drug. I try to tap into a new energy with each new drug. One of these times the magic will happen... With Hope and Best Wishes, Jo (moderator)

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