I felt that way, it was very depressing. I thought there was no hope. But I told my Rheumatologist and my lab tests were such, that we tried a new prescription, which is Xeljanz, and I feel normal now! I'm not saying it is the answer for everyone, but I am encouraging everyone to keep pushing to change meds until you feel better. I also found a great deal of improvement in swelling and stiffness when I cut out sugar, gluten and alcohol!