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Stomach pain from Xeljanz?

I have been taking Xeljanz for a little over a year and I have also had severe stomach pain. It occurred to me that it might be from the Xeljanz. Has anyone else experienced this side effect from Xeljanz?

Community Answers
  • Mike8087
    8 months ago

    I have not suffered any stomach pain from Xeljanz.

  • Mary Sophia Hawks moderator
    10 months ago

    Stomach pain is a common side effect of Xeljanz. I was already on protonix for GERD, and I have not suffered any stomach pain from Xeljanz. If the Xeljanz works for you, then I would suggest seeing your MD about something for the stomach. It’s easier to treat the stomach pain than the symptoms of RA.


  • Kimberly
    12 months ago

    Where exactly is the stomach pain located? (Upper gastric? Belly button? Side?) Does eating aggravate it? Antacids help?

  • jhundley2018
    12 months ago

    I also have been on Xeljanz for some time–maybe two or more years. Now I am having stomach pains, gas, and believe that it is from the meds. so I am off and now the pain is intense. But I got off the meds for a surgery on toe (from RA). Now as I get back on it, it does not seem to relieve the pain. So I have questions also.

  • Richard Faust moderator
    1 year ago

    Hi Nanaamc. On top of the great information on Xeljanz side effects provided by Monica, thought you might be interested in hearing a personal experience. My wife, Kelly Mack (a contributor here), just switched to Xeljanz this winter. She wrote about the experience here: In the article she discusses headaches and since then, like you, stomach issues have arisen, although not severe pain. It is not uncommon for initial side effects to fade and her doctor is monitoring for now to see if hers do. You mention that you have been on the drug for over a year, so your doctor will need to advise. Wishing you the best. Richard ( Team)

  • Monica Y. Sengupta moderator
    1 year ago

    Hi Nanaamc,

    I am so sorry you have stomach pain!! Here is the link to the Xeljanz side effects article:

    It does show that abdominal pain can be a side effect of the medication. However, it’s very important you speak to your doctor about any symptoms you have.

    All the best, Monica ( Moderator)

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