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Methotrexate side effect

Has anyone experienced swelling and a red face thats hot to touch after taking methotrexate injection? This happens to me the day after I take my injection and I told my Dr about it today and she seem to blow off my question about it.

  1. i use and like using injectable MTX for over 8 years. I have not experienced this. Which is not to say it is not happening to you at all. One thing i have learned over the last 20+ years is that no two patients are anything like each other.

    I suggest that perhaps when you talk to your doctor about this that you ask about other DMARD's that might work better. MTX is one of four typical medications we use. Hydroxychloroquine, Leflunomide, and Sulfasalazine are the other three. Perhaps one of this might work out better.

    1. Hello, my dr switched me to hydroxychloroquine. The weird thing is that she dismissed the fact that my face is swelling and turning red. I was on methotrexate for almost 6 months and only a slight change in my blood work.

      1. Hi . I'm glad you got on a new medication. It will be interesting to see if the switch to hydroxychloroquine eliminates your swelling and redness. Keep us posted if you don't mind. I will be thinking of you. -Lori (Team Member)

    2. It's been 2 weeks detoxing from methotrexate and the swelling and redness is gone. I will start hydroxychloroquine today.

      1. , fingers crossed that hydroxychloroquine works well for you (with minimal side effects)!

        Keep us posted, if you feel comfortable doing so!

        Best, Erin, Team Member.

    3. Just sores in mouth and boils between my legs and private parts

      1. I had terrible mouth sores a when the RA caused me to have cancer, and it was awful. It took two weeks and medication to get rid of, and then my taste buds weren’t right for weeks. As for other skin issues I have to make sure to take very good care of my skin and keep it clean or I end up with some of the similar things that you talked of. For me, one of the worst spots is on the side of my nose, although it can be anywhere. Just know you are not alone! Keep on keepin’ on, DPM

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