I've been on Xeljanz for about 5 months now. It seems like I'm tolerating it well. It's so much better than an injection or infusion! I really hate needles so trying to self-inject caused me a ton of stress so being able to take a pill has really helped my mental state.
I haven't really noticed much change in my RA but that can be a good thing. I am not doing worse, so that's positive. But I'm not sure how well it's helping. But I have noticed that my morning stiffness is much better. I used to be stiff for a good 2 hours, but now it's more like 30 minutes to an hour (depending on weather and prior day's activities). I still get the occasional flare but I think that they may not last as long.
The only concern I have is that I've had some asthma-like issues (I don't really have asthma but seems to be aggravated by allergies) and a cough since the beginning of August. I did have an upper respiratory infection that cleared up with antibiotics but the cough still lingers. I know having RA causes a longer recovery time, but I'm not sure if this is related to that or a bad side-effect of the Xeljanz. My cough is better, but I still have it and my voice is quite hoarse and rough. So, I'll see if the cough continues to get better. If not, then maybe it is a side effect of the Xeljanz that I"ll have to determine if I can live with it. I had a chest x-ray done last week that was all clear so I just have to wait and see. Good luck!