Hi . First, let me start by noting that everyone's experience is different. That said, it can be good to hear about other people's experiences as your body adjusts to the new treatment. This article with input from the community on their experiences with JAK inhibitors, including Xeljanz, may be of interest: https://rheumatoidarthritis.net/living/jak-inhibitor-reviews. I can also tell you that my wife, Kelly Mack (a contributor here), used Xeljanz to little effect and with side effects that necessitated finding a different treatment. That said, a friend of ours used it successfully for years. Hoping your experience is more like this last one. Best, Richard (RheumatoidArthritis.net Team)