Hi, I was diagnosed in 2022 put on Methotrexate doing well until April 2026 I have been suffering with chronic daytime fatigue. Is this a side effect of the disease.
Hi . Unfortunately, yes, fatigue is a major symptom of RA for many. Our contributors have written quite a bit on this topic. Here is an article from my friend and fell site team member that sums it up pretty well: https://rheumatoidarthritis.net/living/morning-fatigue. I also want to call your attention to the extensive comments section which includes discussion of some of the research into the causes of autoimmune condition fatigue, such as inflammatory cytokines breaking through the blood-brain barrier or also impacted cellular energy. Traditionally doctors haven't really understood fatigue (see: https://rheumatoidarthritis.net/living/ra-fatigue-complex-poorly-understood) and tend to simply treat the rest of the disease and hope fatigue comes along for the ride in improving. Hopefully the more recent research will lead to real treatments for this symptom. I also want to note that methotrexate can cause fatigue. In particularly, there is the methotrexate "hangover" that often lasts for about 48 hours after taking. Considering that the jump in fatigue is fairly recent, don't hesitate to ask your doctor if there is any change in your inflammation numbers and also whether your treatment should be adjusted. Hope this information is helpful and that others chime in with their thoughts. Best, Richard (Team Member)
Sussiejan4Member
Thank you Richard for the information and links you have sent, just makes me feel I am not alone. ❤️
Erin RushCommunity Admin
Hi, !
I really can't offer any better input than Richard already offered, but I just wanted to chime in and offer some support as you try to get a handle on your fatigue. Members of this community understand how debilitating fatigue can be. You're not alone when you're here!